● Treatment Overview

SIRT: Selective Internal Radiation Therapy

■ Concept of SIRT
■ Science & Specifications of SIR-Spheres

● Published Outcomes
● Patient Selection
● Treatment Planning

Pre-Treatment Testing
Treatment Issues

■ MAA Spect
■ Dosimetry
■ Administration Technique
■ Side Effects
■ Discharge
■ Radiation Safety

● Clinical Studies

SIRT Advantages

● Sphere treatment is a minimally invasive procedure and is usually performed as an outpatient procedure
● Spheres are reimbursed by Medicare when delivered as an outpatient procedure
● Spheres offer patients who have unresectable metastatic tumors an alternative therapy to prolong survival.
● SYS chemotherapy can resume 4 weeks after treatment
● Sphere treatment can downstage tumors and allow for surgical resection

Conclusions:
● All patients with liver cancer are potential candidates for SIRT
● SIRT needs a team for effective treatment
● SIR-Spheres are an adjunct to, not a replacement, for chemotherapy.

The earlier in the treatment process, the better the outcomes

●Sir-Spheres are active against all tumor sizes
● Patient may be downstaged to resection following treatment